Evidence-Based GLP-1 Guidance
GLP-1 medications explained — honestly.
Evidence-based guides to Wegovy, Mounjaro, and NHS weight loss options for women in the UK. Written by Amy Henderson, researcher and science writer.
Amy Henderson — women's health researcher
Amy Henderson spent four years covering GLP-1 medications for women's health publications before launching GLP-1 Guide. She's not a doctor — but she reads the studies, talks to real patients, and tells you what the clinic websites won't.
Read Amy's story →Evidence-Based Only
Peer-reviewed research. No influencer fluff.
AI-Assisted Research
Every article fact-checked using Claude AI
UK-Focused
NHS, private clinics, UK prescribing rules
What You'll Find Here
Evidence-based GLP-1 guidance — not marketing copy.
Semaglutide & Tirzepatide
Ozempic, Mounjaro, Wegovy — how they work, what to expect, and how to get the most from treatment. Evidence-based. No hype.
Managing Nausea & More
Practical guides to managing side effects so you can stay on treatment and see results.
Eating on GLP-1
What to eat, what to avoid, how much protein you actually need, and how to protect muscle mass while in a calorie deficit on treatment.
Trusted Partners
Medications compared
| Medication | Active ingredient | Weight loss | NHS available? | Private cost |
|---|---|---|---|---|
| Mounjaro | Tirzepatide | ~22% avg | Limited | ~£200/mo |
| Wegovy | Semaglutide 2.4mg | ~15% avg | Specialist only | ~£170/mo |
| Ozempic | Semaglutide 1mg | ~9-12% avg | Diabetes only | ~£80/mo |
* Costs are estimates based on UK private clinic pricing as of early 2026. NHS availability changes. Always verify with your GP.
Side effects and management
Nausea
CommonStart on lowest dose, eat smaller meals, avoid fatty foods during titration.
Constipation
CommonIncrease fibre and water intake. Most resolves as dose stabilises.
Injection site reactions
OccasionalRotate injection sites. Reactions are usually mild and temporary.
Fatigue
OccasionalOften linked to reduced caloric intake. Ensure adequate protein.
Pancreatitis (rare)
RareStop immediately and seek medical attention if you experience severe abdominal pain.
Common questions
Can I get Mounjaro on the NHS?
Currently limited — NHS England has approved it for specialist weight management services only. Most people access it privately. This is likely to expand as the NICE guidance is updated.
Do I need a prescription?
Yes. GLP-1 medications require a prescription in the UK. You can get one via your GP or through a regulated online clinic after a medical consultation.
What happens when I stop taking it?
Weight regain is common after stopping — studies show most people regain two-thirds of lost weight within 2 years. These are long-term medications, not short courses.
How much does it cost privately?
Roughly £80–£200 per month depending on the medication and dose. Costs are coming down as generics arrive. Most clinics charge a consultation fee on top.