Updated June 2026
Compare GLP-1 medications UK
Every GLP-1 medication available in the UK compared side by side. Dose, frequency, cost, half-life, weight loss evidence, and where to access each one.
Compare UK clinics →| Medication | Drug | Type | Dose range | Frequency | Half-life | Avg weight loss | NHS available | Private cost/month | Guide | Find a clinic |
|---|---|---|---|---|---|---|---|---|---|---|
| WegovyMost prescribed | Semaglutide | Injection | 0.25mg → 2.4mg | Weekly | 7 days | ~15% | ✓ | £149–£299 | Read guide → | Get started → |
| MounjaroHighest weight loss | Tirzepatide | Injection | 2.5mg → 15mg | Weekly | 5 days | ~22% | – | £149–£249 | Read guide → | Get started → |
| OzempicMost researched | Semaglutide | Injection | 0.25mg → 2mg | Weekly | 7 days | ~12% | ✓ | £100–£200 | Read guide → | Get started → |
| RybelsusNeedle-free | Semaglutide (oral) | Tablet | 3mg → 14mg | Daily | 7 days | ~8% | ✓ | £80–£180 | Read guide → | Get started → |
| VictozaDaily injection | Liraglutide | Injection | 0.6mg → 1.8mg | Daily | 13 hours | ~8% | ✓ | £80–£150 | Read guide → | Get started → |
| SaxendaLicensed for weight | Liraglutide | Injection | 0.6mg → 3mg | Daily | 13 hours | ~8% | ✓ | £150–£250 | Read guide → | Get started → |
Costs shown are typical private clinic prices. NHS availability depends on eligibility. Always consult a qualified prescriber. Affiliate disclosure: clinic links may earn a commission.
Which GLP-1 is right for you?
Best if...
I want maximum weight loss
Mounjaro (tirzepatide)
22% average weight loss in SURMOUNT trial. Dual GIP+GLP-1 action outperforms semaglutide alone.
Mounjaro guide →Best if...
I want needle-free
Rybelsus (oral semaglutide)
Daily tablet instead of weekly injection. Slightly lower weight loss but no needles.
Oral GLP-1 guide →Best if...
I want the most studied option
Wegovy (semaglutide 2.4mg)
STEP trials are the most comprehensive weight loss data ever published. UK-licensed for obesity.
Wegovy vs Ozempic →Best if...
I want the cheapest option
Ozempic (off-label)
Semaglutide at the 1mg dose via private clinic is the lowest-cost semaglutide option, typically from £100/month.
Compare clinic costs →Frequently asked questions
Which GLP-1 causes the most weight loss?
Mounjaro (tirzepatide) produces the highest average weight loss at around 22% of body weight in clinical trials. Wegovy (semaglutide 2.4mg) comes second at around 15%. Both significantly outperform older GLP-1 medications like Saxenda and Victoza.
What is the difference between Ozempic and Wegovy?
Both contain semaglutide, but at different doses. Ozempic is licensed for type 2 diabetes at up to 2mg weekly. Wegovy is licensed specifically for weight loss at up to 2.4mg weekly. Wegovy produces greater weight loss because of the higher dose, but is more expensive. Many UK clinics prescribe Ozempic off-label for weight loss at lower cost.
Can I get GLP-1 medication on the NHS?
Yes, but access is restricted. Wegovy and Saxenda are available via NHS specialist weight management services for patients with a BMI over 35 plus a weight-related condition, or BMI over 40. Waiting lists are long. Most people access GLP-1 medications privately through online clinics in 1-2 weeks.
How much does GLP-1 medication cost privately in the UK?
Private GLP-1 costs range from around £80-£150 per month for Ozempic to £149-£299 per month for Wegovy and Mounjaro depending on the clinic and dose. Most clinics include online doctor consultations in the price. Compare clinics carefully as monitoring quality varies significantly.
Is there an oral GLP-1 medication available in the UK?
Rybelsus (oral semaglutide) is available in the UK and licensed for type 2 diabetes. It produces slightly less weight loss than injectable semaglutide because oral absorption is lower. Oral tirzepatide is in late-stage trials. See our full guide to oral GLP-1 options.
Ready to start?
Compare UK clinics on cost, monitoring quality, and medication range. Most people are prescribed within 1-2 weeks.
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