What to Expect in Your First Month on GLP-1
Starting a GLP-1 medication like Ozempic, Wegovy, or Mounjaro is a significant step. Here's what the first four weeks actually look like, based on real experiences and clinical data.
Week 1: The Adjustment Period
Most people start on the lowest dose (typically 0.25mg for semaglutide). You may experience:
- Nausea — usually mild, peaks around day 3-4
- Reduced appetite — this is the medication working
- Fatigue — your body is adapting to lower blood sugar
Week 2: Finding Your Rhythm
Side effects typically begin to ease. You'll notice:
- Smaller portions feel satisfying
- Fewer food cravings
- More consistent energy levels
Week 3-4: The New Normal
By now, your body has adjusted to the medication. Focus on:
- Protein intake (aim for 60-80g daily minimum)
- Hydration (2-3 litres daily)
- Movement (walking counts)
Common Questions
How much weight will I lose? Most people lose 1-3% of body weight in the first month. This is healthy and sustainable.
When do I increase the dose? Typically every 4 weeks, following your prescriber's protocol.
Bottom Line
The first month is about adjustment, not dramatic results. Trust the process, manage side effects, and build habits that will sustain you long-term.