Best GLP-1 Prescribers UK 2026: Wegovy, Mounjaro & Ozempic Compared

The clinical evidence for GLP-1 receptor agonists is now overwhelming. Tirzepatide (Mounjaro) produced 20.9% mean weight loss at 72 weeks in SURMOUNT-1. Semaglutide (Wegovy) produced 14.9% at 68 weeks in STEP 1. When those two went head-to-head in SURMOUNT-5, Mounjaro pulled 20.2% vs Wegovy's 13.7%.

The question is no longer "do these medications work?" It is "where do I get them, and who will actually look after me while I take them?"

This comparison covers the five most-used UK online prescribers: Pharmacy2U, Click Pharmacy, Boots Health Hub, Superdrug Online Doctor, and Numan. Pricing is current as of May 2026 but does change — always check direct.

---

What Separates a Good GLP-1 Prescriber from a Bad One

Before the head-to-head, it helps to know what you are actually evaluating. The medication is the same molecule wherever you get it. What differs is:

Consultation quality — is someone actually reviewing your medical history, checking contraindications (personal or family history of medullary thyroid cancer, pancreatitis, severe kidney disease), and setting appropriate expectations? Or is it a checkbox form?

Titration support — flexible dose titration, where you stay at a lower dose until side effects settle, reduces dropout rates from 19% to 2% according to a 2026 Frontiers study. Does your prescriber allow this, or do they auto-escalate you?

Ongoing monitoring — blood pressure, HbA1c, kidney function and lipids can shift on GLP-1 therapy. A good prescriber will prompt you to retest. See our GLP-1 blood test panel guide for what to track.

Side effect support — nausea affects around 44% of patients (versus 16% on placebo). Does your prescriber have a clinical pathway when you contact them about side effects, or do they just send you an FAQ?

Price transparency — some services quote a low consultation fee then charge separately for each follow-up, prescription renewal, and delivery. Others are all-in monthly. Both are fine, but you need to compare total annual cost, not headline price.

---

UK GLP-1 Prescriber Comparison 2026

Prices are indicative for starter doses (e.g. Wegovy 0.25mg/week or Mounjaro 2.5mg/week). Higher maintenance doses cost more. Verify current pricing directly.

---

Pharmacy2U

Pharmacy2U is the UK's largest online pharmacy, and they bring that infrastructure to GLP-1 prescribing. They are NHS-registered and also run a private weight management service.

What they prescribe: Wegovy (semaglutide) and Mounjaro (tirzepatide).

The consultation process: An online health questionnaire covering your BMI, current medications, relevant medical history, and weight-loss goals. A pharmacist or prescriber reviews and, if appropriate, issues the prescription. You do not speak to a clinician in real time unless there is a query.

Pricing: Starter doses begin around £149/month. Maintenance doses (Wegovy 2.4mg or Mounjaro 15mg) typically run £220-£270/month. Consultation is included in the first month.

Delivery: Next-day delivery via their existing dispensary. Reliable and discreet.

Support: Pharmacy2U include follow-up prescription reviews and allow you to contact their pharmacy team. They are not a 24/7 medical service, but response times are generally fast during business hours.

Best for: People who want a trusted, established UK pharmacy behind their prescription. NHS-registered status matters to some patients.

---

Click Pharmacy

Click Pharmacy is a CQC-registered online pharmacy that has built a dedicated weight management pathway. They are one of the few UK services still listing Ozempic (semaglutide 1mg) alongside Wegovy and Mounjaro.

What they prescribe: Wegovy, Mounjaro, and Ozempic (off-label for weight loss — be aware this is 1mg semaglutide, not the 2.4mg Wegovy formulation).

The consultation process: Online questionnaire followed by prescriber review. Click Pharmacy are clear about eligibility — BMI 30+ (or 27+ with at least one weight-related health condition). Their form is detailed and asks about prior weight-loss attempts, current comorbidities, and contraindications.

Pricing: Wegovy from approximately £139/month for 0.25mg starter. Mounjaro from around £139/month for 2.5mg starter. Pricing is competitive relative to the market.

Delivery: Free delivery included. Generally dispatched within 1–2 business days of prescription approval.

Support: Online chat with the pharmacy team. Side effect queries can be handled through their patient portal.

Best for: Price-conscious patients who want a real prescriber reviewing their case, and anyone who wants Mounjaro as the default first choice.

---

Boots Health Hub

Boots is the most recognised pharmacy brand in the UK, and that familiarity comes with both advantages and disadvantages for GLP-1 prescribing.

What they prescribe: Wegovy (semaglutide). Mounjaro availability has been inconsistent — check before committing.

The consultation process: Available online or in-store at Boots Health Hub locations. The in-store option is genuinely different from competitors — you speak to a pharmacist face-to-face. For some patients this feels more medically credible.

Pricing: Boots runs at a premium. Expect to pay around £199/month at starter doses. At maintenance doses (2.4mg Wegovy), costs can exceed £280/month.

Support: In-store pharmacist access is a genuine differentiator. You can walk in and talk to someone. Online support is standard.

Limitation: The premium pricing is hard to justify when Pharmacy2U and Click Pharmacy offer equivalent clinical oversight at a lower cost. You are paying partly for the Boots brand.

Best for: Patients who want the option of face-to-face pharmacist contact and are less price-sensitive.

---

Superdrug Online Doctor

Superdrug's Online Doctor service is one of the UK's most-used digital health platforms, and they added Wegovy to their portfolio as prescribing rolled out.

What they prescribe: Wegovy. Mounjaro availability is limited — check current stock.

The consultation process: Fully online questionnaire reviewed by a prescriber. Fast turnaround (often same or next day).

Pricing: From approximately £179/month for starter doses. Renewal prescriptions are slightly cheaper.

Support: This is the weakest area. Superdrug Online Doctor provides basic patient support but is not known for proactive follow-up or easy side effect escalation. You get a prescription service, not a weight management programme.

Best for: Patients who have already been on GLP-1 therapy and need a reliable repeat prescription service. Less suitable for first-time users who want clinical guidance.

---

Numan

Numan started as a men's health platform but has expanded into weight management for all genders. Their GLP-1 service includes dedicated clinical team access.

What they prescribe: Wegovy and Mounjaro.

The consultation process: Online questionnaire reviewed by a GP (not just a pharmacist). Numan's clinical team will follow up if there are queries.

Pricing: From approximately £159/month. The Numan subscription model includes ongoing clinical support, which makes the monthly price more defensible.

Support: The strongest among the five reviewed here. Dedicated patient dashboard, messaging with the clinical team, and structured check-in prompts.

Best for: Patients who want sustained clinical involvement throughout their treatment, and those who have been refused elsewhere due to complex medical histories.

---

Side Effects and What to Expect

Whichever prescriber you choose, the side effect profile is the same — the molecule is identical. Nausea is the most common early side effect, affecting around 44% of patients in trials versus 16% on placebo. This typically peaks in the first 8–12 weeks and reduces over time.

Read our GLP-1 side effects guide for practical management strategies.

---

How Titration Works — and Why It Matters

All current UK GLP-1 prescribing follows a dose escalation schedule. Wegovy starts at 0.25mg/week and increases monthly up to 2.4mg/week. Mounjaro starts at 2.5mg/week and increases up to 15mg/week.

The key clinical point: you do not have to escalate on schedule. If nausea or other GI side effects are poorly controlled at your current dose, staying at that dose for another 4 weeks before moving up is safe and supported by the evidence. A 2026 Frontiers paper found flexible titration reduced discontinuation from 19% to 2%.

Ask your prescriber explicitly: "If I am struggling with side effects, can I delay my next dose increase?" The answer should be yes. If it is not, that is a red flag.

---

The SURMOUNT-5 Data: Does It Change Which Drug to Pick?

The 2025 SURMOUNT-5 head-to-head trial (NEJM, DOI 10.1056/NEJMoa2500439) randomised patients to Mounjaro versus Wegovy. Mounjaro produced 20.2% mean weight loss versus 13.7% for Wegovy.

For most patients starting fresh, this data supports Mounjaro as first choice if cost is manageable and there are no contraindications. Wegovy remains a legitimate option — the 14.9% figure is still clinically meaningful — and the new 7.2mg Wegovy formulation (MHRA-approved January 2026) achieves 20.7% weight loss, narrowing the gap.

For an in-depth comparison, see our Mounjaro vs Wegovy UK 2026 guide.

---

Monitoring: What Good Follow-Up Looks Like

GLP-1 therapy is not a medication you take without oversight. Before starting, you should have (or have recently had) blood tests covering HbA1c, kidney function, liver function, and lipids. Thyroid function is also worth checking given the theoretical thyroid c-cell signal from animal data (though no causal link has been established in humans).

Our GLP-1 blood test panel guide covers exactly what to ask for and how to interpret the results.

---

Which Prescriber Should You Choose?

Choose Pharmacy2U if you want NHS-adjacent credibility, reliable delivery, and a pharmacy infrastructure you already know.

Choose Click Pharmacy if price is a priority and you want competitive rates without sacrificing prescriber quality. Their Mounjaro pricing is particularly strong.

Choose Boots if face-to-face pharmacist access is important to you and you are not price-sensitive.

Choose Superdrug if you already know the medication, need a repeat prescription service, and want the lowest friction.

Choose Numan if you want the most hands-on clinical support and are willing to pay a modest premium for it.

---

Frequently Asked Questions

Can I switch prescribers mid-treatment? Yes. Your prescription history is yours. A new prescriber will ask about your current dose and review your health status before continuing. There is no clinical reason you cannot switch.

What BMI do I need? Private prescribers generally require BMI 30+ or BMI 27+ with at least one weight-related health condition (type 2 diabetes, hypertension, dyslipidaemia, sleep apnoea, etc.). See our GLP-1 eligibility guide.

Is a consultation fee on top of the medication cost? For most providers listed here, the first consultation is bundled into the first month's cost. Check each provider's pricing page carefully — renewal consultation fees vary.

What if I get side effects? Contact your prescriber. Do not try to manage severe nausea, vomiting, or abdominal pain alone. Most cases are mild and manageable with dose adjustment and dietary changes. See our nausea and side effects guide.

Should I combine GLP-1 therapy with supplements? Some nutritional supplements support GLP-1 treatment outcomes — particularly protein, magnesium, and electrolytes. See our protein on GLP-1 complete guide for evidence-based recommendations.